Klinefelter syndrome is a chromosomal abnormality in which the male has an extra chromosome known as the X chromosome, so the male’s genetic makeup is XXY instead of XY.

This defect in the number of chromosomes results in many symptoms and physical problems. The patient with Klinefelter syndrome does not detect the disease in the early stages of life. Klinefelter syndrome is a rare condition that affects one in every 660 males.

Early diagnosis of Klinefelter syndrome allows for anticipation of future changes and helps control symptoms. Many people manage the syndrome well and lead a fairly normal life. [4]

In this article, we review the most prominent symptoms of Klinefelter syndrome, and know if it is a serious condition?

Symptoms of Klinefelter syndrome

Symptoms of Klinefelter syndrome vary from one age stage to another. Some people cannot detect their infection until after puberty, while others have symptoms since childhood. The following are the most important symptoms in all age stages:

Klinefelter syndrome in infants

The baby shows the following symptoms:

  • The scrotum is empty and the testicles have not fallen into it as in normal children.
  • The appearance of a hernia in the newborn.
  • The child is slow in learning to sit, walk, and speak.
  • Muscles are weaker than normal.
  • The child is calmer than normal.

Klinefelter syndrome in children

In childhood, these symptoms appear:

  • The child feels shy and lacks self-confidence all the time.
  • A child’s energy levels are low most of the time.
  • The child has problems in writing, solving arithmetic operations.
  • It is difficult for the child to form friendships or express oneself.

Klinefelter syndrome in young people

Symptoms of Klinefelter syndrome in young people are as follows:

  • Less hair on the body and face.
  • Muscles grow slowly.
  • The young man has arms and legs that are longer than normal.
  • Breast size is larger than normal.
  • A young person does not reach puberty, or reaches puberty at a very late age.
  • The penis is small, and the testicle is smaller than normal.

Klinefelter syndrome in men

Symptoms in men develop as follows:

Is Klinefelter syndrome dangerous?

Before we answer this important question, we should learn how Klinefelter syndrome is detected, and how doctors diagnose it.

Klinefelter syndrome is often discovered when a man undergoes fertility tests. The doctor can suspect the infection on the outward examination, but it must be confirmed by performing a blood test, to confirm the presence of the extra X chromosome.

Returning to the answer to the question of how dangerous Klinefelter syndrome is, this syndrome is not necessarily dangerous, but treatment can help avoid or reduce its symptoms. [3]

Is Klinefelter syndrome a genetic disease?

We cannot consider Klinefelter syndrome as a genetic disease, as it is an abnormal condition in the distribution of chromosomes during the division of eggs. The normal distribution occurs, which is that each egg contains one sex chromosome of type X, in this case an unknown error occurs, resulting in abnormal eggs, One of the eggs contains two X chromosomes, meaning that the structure of the egg is 22 + XX, and the other has a structure of 22 + 0, which means that it does not have a sex chromosome.

A child with Klinefelter syndrome is produced when a 22+Y sperm is fertilized with an abnormal 22+XX egg, resulting in a 44+XXY baby. [2]